QQQ and VOO are both made up of large US companies, but they are built differently. QQQ follows the Nasdaq-100, 100 large non-financial companies listed on the Nasdaq and heavily tilted to technology. VOO follows the S&P 500, roughly 500 companies across every sector.

The result is a more concentrated, more growth-oriented fund (QQQ) against a broader, more balanced one (VOO).